Denosumab (Prolia, Xgeva) (J0897): Medicare covered diagnoses & ICD-10 codes

Prolia, Xgeva, and biosimilars · Medicare Part B (physician-administered) · 409 covered ICD-10 codes

Medicare pays for Denosumab (Prolia, Xgeva) (J0897) under Part B when the claim carries a covered diagnosis. National Government Services, Inc. defines local coverage in Billing & Coding Article A52399 (LCD L33394), which lists 409 covered ICD-10 codes — the complete, current list is below, grouped by condition. CMS last revised this article 03/27/2026; we reviewed it Jun 29, 2026.

Page reviewed Jun 29, 2026 · from CMS Article A52399 (CMS last revised 03/27/2026)

Quick answer

Medicare benefit
Part B (physician-administered)
Covered diagnoses
409 ICD-10 codes
Governing policy
A52399 / L33394
Contractor (MAC)
National Government Services, Inc.
CMS article revised
03/27/2026
Page reviewed
Jun 29, 2026
HCPCS codes covered:
J0897J3590Q5136Q5157Q5158Q5159
Coverage varies by Medicare Administrative Contractor (MAC). This list is National Government Services, Inc.'s policy (Article A52399), which administers Part B in Illinois, Minnesota, Wisconsin, Connecticut, Maine, Massachusetts +4 more. In another state? Other MACs may publish a different covered list — find your MAC by state →

What Medicare pays for Denosumab (Prolia, Xgeva) (2026 Q2)

Once a claim carries a covered diagnosis, Medicare Part B reimburses the drug at the ASP + 6% payment limit. Current allowed amounts per billing unit:

HCPCSDescriptionPer unitAllowed (ASP + 6%)
J0897Denosumab injection1 mg$29.507
Q5136Inj. denosumab-bbdz, 1 mg1 mg$27.914
Q5157Inj, denosumab-bmwo, 1 mg1 mg$26.209
Q5158Inj, denosumab-bnht, 1 mg1 mg$29.797

Source: CMS ASP Drug Pricing File, 2026 Q2. Payment = ASP + 6% per unit; multiply by units billed (watch JZ/JW wastage). Your patient's share is typically 20% after the deductible. Estimate the full cost & patient out-of-pocket →

Denosumab (Prolia, Xgeva) is a physician-administered biologic billed under Medicare Part B (not the Part D pharmacy benefit). Under Part B, Medicare pays the practice for the drug (HCPCS J0897) plus its administration — but only when the claim's diagnosis (ICD-10) code supports medical necessity. Each MAC publishes the specific covered diagnoses in a Billing & Coding Article; a claim with a diagnosis outside that list is typically denied as not medically necessary (CO-50).

Covered ICD-10 diagnoses for Denosumab (Prolia, Xgeva)

The 409 codes below are the diagnoses National Government Services, Inc. accepts for J0897 under Article A52399, grouped exactly as CMS groups them and organized by condition category for scanning. Use the filter in each group to find a specific code or condition.

Group 1 — 161 covered diagnoses (applies to Q5159, J3590, Q5157, Q5158, J0897, Q5136)

Xgeva® Biosimilar Indications Effective 01/01/2026 Demosumab-dssb ( Xbryk ) should be reported using HCPCS code Q5159 01/01/2026, Denosumab-nxxp ( Bilprevda®) should be reported using HCPCS code J3590 Effective 10/1/2025, Demosumab-bmwo ( Osenvelt®) should be reported using HCPCS code Q5157 Effective 10/1/2025, Demosumab-bnht ( Bomyntra ) should be reported using HCPCS code Q5158 Effective 10/1/2025, Denosumab ( Xgeva®) should be reported using HCPCS J0897 Effective 10/1/2025, Denosumab-bbdz ( Wyost®) should be reported using HCPCS Q5136 For the treatment of patients with bone metastases from solid tumors. Note: multiple myeloma, lymphoma and other cancers of the blood are not considered solid tumors). Effective for dates of service on or after 01/04/2018, the FDA has approved denosumab (Xgeva®) for the treatment of skeletal-related events in patients with multiple myeloma. For the treatment of adults and skeletally mature adolescents with giant cell tumor of bone that is unresectable or where surgical resection is likely to result in severe morbidity. ICD-10-CM code E83.52 should be used to report management of hypercalcemia of malignancy .

Diseases of the musculoskeletal system & connective tissue (133)

ICD-10Covered diagnosis
M84.511APathological fracture in neoplastic disease, right shoulder, initial encounter for fracture
M84.511DPathological fracture in neoplastic disease, right shoulder, subsequent encounter for fracture with routine healing
M84.511GPathological fracture in neoplastic disease, right shoulder, subsequent encounter for fracture with delayed healing
M84.511KPathological fracture in neoplastic disease, right shoulder, subsequent encounter for fracture with nonunion
M84.511PPathological fracture in neoplastic disease, right shoulder, subsequent encounter for fracture with malunion
M84.511SPathological fracture in neoplastic disease, right shoulder, sequela
M84.512APathological fracture in neoplastic disease, left shoulder, initial encounter for fracture
M84.512DPathological fracture in neoplastic disease, left shoulder, subsequent encounter for fracture with routine healing
M84.512GPathological fracture in neoplastic disease, left shoulder, subsequent encounter for fracture with delayed healing
M84.512KPathological fracture in neoplastic disease, left shoulder, subsequent encounter for fracture with nonunion
M84.512PPathological fracture in neoplastic disease, left shoulder, subsequent encounter for fracture with malunion
M84.512SPathological fracture in neoplastic disease, left shoulder, sequela
M84.521APathological fracture in neoplastic disease, right humerus, initial encounter for fracture
M84.521DPathological fracture in neoplastic disease, right humerus, subsequent encounter for fracture with routine healing
M84.521GPathological fracture in neoplastic disease, right humerus, subsequent encounter for fracture with delayed healing
M84.521KPathological fracture in neoplastic disease, right humerus, subsequent encounter for fracture with nonunion
M84.521PPathological fracture in neoplastic disease, right humerus, subsequent encounter for fracture with malunion
M84.521SPathological fracture in neoplastic disease, right humerus, sequela
M84.522APathological fracture in neoplastic disease, left humerus, initial encounter for fracture
M84.522DPathological fracture in neoplastic disease, left humerus, subsequent encounter for fracture with routine healing
M84.522GPathological fracture in neoplastic disease, left humerus, subsequent encounter for fracture with delayed healing
M84.522KPathological fracture in neoplastic disease, left humerus, subsequent encounter for fracture with nonunion
M84.522PPathological fracture in neoplastic disease, left humerus, subsequent encounter for fracture with malunion
M84.522SPathological fracture in neoplastic disease, left humerus, sequela
M84.531APathological fracture in neoplastic disease, right ulna, initial encounter for fracture
M84.531DPathological fracture in neoplastic disease, right ulna, subsequent encounter for fracture with routine healing
M84.531GPathological fracture in neoplastic disease, right ulna, subsequent encounter for fracture with delayed healing
M84.531KPathological fracture in neoplastic disease, right ulna, subsequent encounter for fracture with nonunion
M84.531PPathological fracture in neoplastic disease, right ulna, subsequent encounter for fracture with malunion
M84.531SPathological fracture in neoplastic disease, right ulna, sequela
M84.532APathological fracture in neoplastic disease, left ulna, initial encounter for fracture
M84.532DPathological fracture in neoplastic disease, left ulna, subsequent encounter for fracture with routine healing
M84.532GPathological fracture in neoplastic disease, left ulna, subsequent encounter for fracture with delayed healing
M84.532KPathological fracture in neoplastic disease, left ulna, subsequent encounter for fracture with nonunion
M84.532PPathological fracture in neoplastic disease, left ulna, subsequent encounter for fracture with malunion
M84.532SPathological fracture in neoplastic disease, left ulna, sequela
M84.533APathological fracture in neoplastic disease, right radius, initial encounter for fracture
M84.533DPathological fracture in neoplastic disease, right radius, subsequent encounter for fracture with routine healing
M84.533GPathological fracture in neoplastic disease, right radius, subsequent encounter for fracture with delayed healing
M84.533KPathological fracture in neoplastic disease, right radius, subsequent encounter for fracture with nonunion
M84.533PPathological fracture in neoplastic disease, right radius, subsequent encounter for fracture with malunion
M84.533SPathological fracture in neoplastic disease, right radius, sequela
M84.534APathological fracture in neoplastic disease, left radius, initial encounter for fracture
M84.534DPathological fracture in neoplastic disease, left radius, subsequent encounter for fracture with routine healing
M84.534GPathological fracture in neoplastic disease, left radius, subsequent encounter for fracture with delayed healing
M84.534KPathological fracture in neoplastic disease, left radius, subsequent encounter for fracture with nonunion
M84.534PPathological fracture in neoplastic disease, left radius, subsequent encounter for fracture with malunion
M84.534SPathological fracture in neoplastic disease, left radius, sequela
M84.541APathological fracture in neoplastic disease, right hand, initial encounter for fracture
M84.541DPathological fracture in neoplastic disease, right hand, subsequent encounter for fracture with routine healing
M84.541GPathological fracture in neoplastic disease, right hand, subsequent encounter for fracture with delayed healing
M84.541KPathological fracture in neoplastic disease, right hand, subsequent encounter for fracture with nonunion
M84.541PPathological fracture in neoplastic disease, right hand, subsequent encounter for fracture with malunion
M84.541SPathological fracture in neoplastic disease, right hand, sequela
M84.542APathological fracture in neoplastic disease, left hand, initial encounter for fracture
M84.542DPathological fracture in neoplastic disease, left hand, subsequent encounter for fracture with routine healing
M84.542GPathological fracture in neoplastic disease, left hand, subsequent encounter for fracture with delayed healing
M84.542KPathological fracture in neoplastic disease, left hand, subsequent encounter for fracture with nonunion
M84.542PPathological fracture in neoplastic disease, left hand, subsequent encounter for fracture with malunion
M84.542SPathological fracture in neoplastic disease, left hand, sequela
M84.550APathological fracture in neoplastic disease, pelvis, initial encounter for fracture
M84.550DPathological fracture in neoplastic disease, pelvis, subsequent encounter for fracture with routine healing
M84.550GPathological fracture in neoplastic disease, pelvis, subsequent encounter for fracture with delayed healing
M84.550KPathological fracture in neoplastic disease, pelvis, subsequent encounter for fracture with nonunion
M84.550PPathological fracture in neoplastic disease, pelvis, subsequent encounter for fracture with malunion
M84.550SPathological fracture in neoplastic disease, pelvis, sequela
M84.551APathological fracture in neoplastic disease, right femur, initial encounter for fracture
M84.551DPathological fracture in neoplastic disease, right femur, subsequent encounter for fracture with routine healing
M84.551GPathological fracture in neoplastic disease, right femur, subsequent encounter for fracture with delayed healing
M84.551KPathological fracture in neoplastic disease, right femur, subsequent encounter for fracture with nonunion
M84.551PPathological fracture in neoplastic disease, right femur, subsequent encounter for fracture with malunion
M84.551SPathological fracture in neoplastic disease, right femur, sequela
M84.552APathological fracture in neoplastic disease, left femur, initial encounter for fracture
M84.552DPathological fracture in neoplastic disease, left femur, subsequent encounter for fracture with routine healing
M84.552GPathological fracture in neoplastic disease, left femur, subsequent encounter for fracture with delayed healing
M84.552KPathological fracture in neoplastic disease, left femur, subsequent encounter for fracture with nonunion
M84.552PPathological fracture in neoplastic disease, left femur, subsequent encounter for fracture with malunion
M84.552SPathological fracture in neoplastic disease, left femur, sequela
M84.561APathological fracture in neoplastic disease, right tibia, initial encounter for fracture
M84.561DPathological fracture in neoplastic disease, right tibia, subsequent encounter for fracture with routine healing
M84.561GPathological fracture in neoplastic disease, right tibia, subsequent encounter for fracture with delayed healing
M84.561KPathological fracture in neoplastic disease, right tibia, subsequent encounter for fracture with nonunion
M84.561PPathological fracture in neoplastic disease, right tibia, subsequent encounter for fracture with malunion
M84.561SPathological fracture in neoplastic disease, right tibia, sequela
M84.562APathological fracture in neoplastic disease, left tibia, initial encounter for fracture
M84.562DPathological fracture in neoplastic disease, left tibia, subsequent encounter for fracture with routine healing
M84.562GPathological fracture in neoplastic disease, left tibia, subsequent encounter for fracture with delayed healing
M84.562KPathological fracture in neoplastic disease, left tibia, subsequent encounter for fracture with nonunion
M84.562PPathological fracture in neoplastic disease, left tibia, subsequent encounter for fracture with malunion
M84.562SPathological fracture in neoplastic disease, left tibia, sequela
M84.563APathological fracture in neoplastic disease, right fibula, initial encounter for fracture
M84.563DPathological fracture in neoplastic disease, right fibula, subsequent encounter for fracture with routine healing
M84.563GPathological fracture in neoplastic disease, right fibula, subsequent encounter for fracture with delayed healing
M84.563KPathological fracture in neoplastic disease, right fibula, subsequent encounter for fracture with nonunion
M84.563PPathological fracture in neoplastic disease, right fibula, subsequent encounter for fracture with malunion
M84.563SPathological fracture in neoplastic disease, right fibula, sequela
M84.564APathological fracture in neoplastic disease, left fibula, initial encounter for fracture
M84.564DPathological fracture in neoplastic disease, left fibula, subsequent encounter for fracture with routine healing
M84.564GPathological fracture in neoplastic disease, left fibula, subsequent encounter for fracture with delayed healing
M84.564KPathological fracture in neoplastic disease, left fibula, subsequent encounter for fracture with nonunion
M84.564PPathological fracture in neoplastic disease, left fibula, subsequent encounter for fracture with malunion
M84.564SPathological fracture in neoplastic disease, left fibula, sequela
M84.569APathological fracture in neoplastic disease, unspecified tibia and fibula, initial encounter for fracture
M84.571APathological fracture in neoplastic disease, right ankle, initial encounter for fracture
M84.571DPathological fracture in neoplastic disease, right ankle, subsequent encounter for fracture with routine healing
M84.571GPathological fracture in neoplastic disease, right ankle, subsequent encounter for fracture with delayed healing
M84.571KPathological fracture in neoplastic disease, right ankle, subsequent encounter for fracture with nonunion
M84.571PPathological fracture in neoplastic disease, right ankle, subsequent encounter for fracture with malunion
M84.571SPathological fracture in neoplastic disease, right ankle, sequela
M84.572APathological fracture in neoplastic disease, left ankle, initial encounter for fracture
M84.572DPathological fracture in neoplastic disease, left ankle, subsequent encounter for fracture with routine healing
M84.572GPathological fracture in neoplastic disease, left ankle, subsequent encounter for fracture with delayed healing
M84.572KPathological fracture in neoplastic disease, left ankle, subsequent encounter for fracture with nonunion
M84.572PPathological fracture in neoplastic disease, left ankle, subsequent encounter for fracture with malunion
M84.572SPathological fracture in neoplastic disease, left ankle, sequela
M84.574APathological fracture in neoplastic disease, right foot, initial encounter for fracture
M84.574DPathological fracture in neoplastic disease, right foot, subsequent encounter for fracture with routine healing
M84.574GPathological fracture in neoplastic disease, right foot, subsequent encounter for fracture with delayed healing
M84.574KPathological fracture in neoplastic disease, right foot, subsequent encounter for fracture with nonunion
M84.574PPathological fracture in neoplastic disease, right foot, subsequent encounter for fracture with malunion
M84.574SPathological fracture in neoplastic disease, right foot, sequela
M84.575APathological fracture in neoplastic disease, left foot, initial encounter for fracture
M84.575DPathological fracture in neoplastic disease, left foot, subsequent encounter for fracture with routine healing
M84.575GPathological fracture in neoplastic disease, left foot, subsequent encounter for fracture with delayed healing
M84.575KPathological fracture in neoplastic disease, left foot, subsequent encounter for fracture with nonunion
M84.575PPathological fracture in neoplastic disease, left foot, subsequent encounter for fracture with malunion
M84.575SPathological fracture in neoplastic disease, left foot, sequela
M84.58XAPathological fracture in neoplastic disease, other specified site, initial encounter for fracture
M84.58XDPathological fracture in neoplastic disease, other specified site, subsequent encounter for fracture with routine healing
M84.58XGPathological fracture in neoplastic disease, other specified site, subsequent encounter for fracture with delayed healing
M84.58XKPathological fracture in neoplastic disease, other specified site, subsequent encounter for fracture with nonunion
M84.58XPPathological fracture in neoplastic disease, other specified site, subsequent encounter for fracture with malunion
M84.58XSPathological fracture in neoplastic disease, other specified site, sequela

Neoplasms (27)

ICD-10Covered diagnosis
C40.01Malignant neoplasm of scapula and long bones of right upper limb
C40.02Malignant neoplasm of scapula and long bones of left upper limb
C40.11Malignant neoplasm of short bones of right upper limb
C40.12Malignant neoplasm of short bones of left upper limb
C40.21Malignant neoplasm of long bones of right lower limb
C40.22Malignant neoplasm of long bones of left lower limb
C40.31Malignant neoplasm of short bones of right lower limb
C40.32Malignant neoplasm of short bones of left lower limb
C40.81Malignant neoplasm of overlapping sites of bone and articular cartilage of right limb
C40.82Malignant neoplasm of overlapping sites of bone and articular cartilage of left limb
C40.91Malignant neoplasm of unspecified bones and articular cartilage of right limb
C40.92Malignant neoplasm of unspecified bones and articular cartilage of left limb
C41.9Malignant neoplasm of bone and articular cartilage, unspecified
C79.51Secondary malignant neoplasm of bone
C90.00Multiple myeloma not having achieved remission
C90.01Multiple myeloma in remission
C90.02Multiple myeloma in relapse
C90.10Plasma cell leukemia not having achieved remission
C90.11Plasma cell leukemia in remission
C90.12Plasma cell leukemia in relapse
C90.20Extramedullary plasmacytoma not having achieved remission
C90.21Extramedullary plasmacytoma in remission
C90.22Extramedullary plasmacytoma in relapse
C90.30Solitary plasmacytoma not having achieved remission
C90.31Solitary plasmacytoma in remission
C90.32Solitary plasmacytoma in relapse
D48.0Neoplasm of uncertain behavior of bone and articular cartilage

Endocrine, nutritional & metabolic diseases (1)

ICD-10Covered diagnosis
E83.52Hypercalcemia

Group 2 — 248 covered diagnoses (applies to Q5158, J3590, Q5157, Q5159, J0897, Q5136)

Prolia® biosimilars indications Treatment of osteoporosis at high risk for fracture Effective 01/01/2026, Demosumab-bnht ( Conexxence ) should be reported using HCPCS code Q5158 Effective 01/01/2026, Denosumab-nxxp ( Bildyos® ) should be reported using HCPCS code J3590 Effective 10/1/2025, Demosumab-bmwo ( Stoboclo ) should be reported using HCPCS code Q5157 Effective 10/1/2025, Demosumab-dssb ( Ospomyv ) should be reported using HCPCS code Q5159 Effective 10/1/2025, Denosumab ( Prolia® ) should be reported using HCPCS J0897 Effective 10/1/2025, Denosumab-bbdz ( Jubbonti® ) should be reported using HCPCS Q5136

Diseases of the musculoskeletal system & connective tissue (206)

ICD-10Covered diagnosis
M80.011AAge-related osteoporosis with current pathological fracture, right shoulder, initial encounter for fracture
M80.011DAge-related osteoporosis with current pathological fracture, right shoulder, subsequent encounter for fracture with routine healing
M80.011GAge-related osteoporosis with current pathological fracture, right shoulder, subsequent encounter for fracture with delayed healing
M80.011KAge-related osteoporosis with current pathological fracture, right shoulder, subsequent encounter for fracture with nonunion
M80.011PAge-related osteoporosis with current pathological fracture, right shoulder, subsequent encounter for fracture with malunion
M80.011SAge-related osteoporosis with current pathological fracture, right shoulder, sequela
M80.012AAge-related osteoporosis with current pathological fracture, left shoulder, initial encounter for fracture
M80.012DAge-related osteoporosis with current pathological fracture, left shoulder, subsequent encounter for fracture with routine healing
M80.012GAge-related osteoporosis with current pathological fracture, left shoulder, subsequent encounter for fracture with delayed healing
M80.012KAge-related osteoporosis with current pathological fracture, left shoulder, subsequent encounter for fracture with nonunion
M80.012PAge-related osteoporosis with current pathological fracture, left shoulder, subsequent encounter for fracture with malunion
M80.012SAge-related osteoporosis with current pathological fracture, left shoulder, sequela
M80.021AAge-related osteoporosis with current pathological fracture, right humerus, initial encounter for fracture
M80.021DAge-related osteoporosis with current pathological fracture, right humerus, subsequent encounter for fracture with routine healing
M80.021GAge-related osteoporosis with current pathological fracture, right humerus, subsequent encounter for fracture with delayed healing
M80.021KAge-related osteoporosis with current pathological fracture, right humerus, subsequent encounter for fracture with nonunion
M80.021PAge-related osteoporosis with current pathological fracture, right humerus, subsequent encounter for fracture with malunion
M80.021SAge-related osteoporosis with current pathological fracture, right humerus, sequela
M80.022AAge-related osteoporosis with current pathological fracture, left humerus, initial encounter for fracture
M80.022DAge-related osteoporosis with current pathological fracture, left humerus, subsequent encounter for fracture with routine healing
M80.022GAge-related osteoporosis with current pathological fracture, left humerus, subsequent encounter for fracture with delayed healing
M80.022KAge-related osteoporosis with current pathological fracture, left humerus, subsequent encounter for fracture with nonunion
M80.022PAge-related osteoporosis with current pathological fracture, left humerus, subsequent encounter for fracture with malunion
M80.022SAge-related osteoporosis with current pathological fracture, left humerus, sequela
M80.031AAge-related osteoporosis with current pathological fracture, right forearm, initial encounter for fracture
M80.031DAge-related osteoporosis with current pathological fracture, right forearm, subsequent encounter for fracture with routine healing
M80.031GAge-related osteoporosis with current pathological fracture, right forearm, subsequent encounter for fracture with delayed healing
M80.031KAge-related osteoporosis with current pathological fracture, right forearm, subsequent encounter for fracture with nonunion
M80.031PAge-related osteoporosis with current pathological fracture, right forearm, subsequent encounter for fracture with malunion
M80.031SAge-related osteoporosis with current pathological fracture, right forearm, sequela
M80.032AAge-related osteoporosis with current pathological fracture, left forearm, initial encounter for fracture
M80.032DAge-related osteoporosis with current pathological fracture, left forearm, subsequent encounter for fracture with routine healing
M80.032GAge-related osteoporosis with current pathological fracture, left forearm, subsequent encounter for fracture with delayed healing
M80.032KAge-related osteoporosis with current pathological fracture, left forearm, subsequent encounter for fracture with nonunion
M80.032PAge-related osteoporosis with current pathological fracture, left forearm, subsequent encounter for fracture with malunion
M80.032SAge-related osteoporosis with current pathological fracture, left forearm, sequela
M80.041AAge-related osteoporosis with current pathological fracture, right hand, initial encounter for fracture
M80.041DAge-related osteoporosis with current pathological fracture, right hand, subsequent encounter for fracture with routine healing
M80.041GAge-related osteoporosis with current pathological fracture, right hand, subsequent encounter for fracture with delayed healing
M80.041KAge-related osteoporosis with current pathological fracture, right hand, subsequent encounter for fracture with nonunion
M80.041PAge-related osteoporosis with current pathological fracture, right hand, subsequent encounter for fracture with malunion
M80.041SAge-related osteoporosis with current pathological fracture, right hand, sequela
M80.042AAge-related osteoporosis with current pathological fracture, left hand, initial encounter for fracture
M80.042DAge-related osteoporosis with current pathological fracture, left hand, subsequent encounter for fracture with routine healing
M80.042GAge-related osteoporosis with current pathological fracture, left hand, subsequent encounter for fracture with delayed healing
M80.042KAge-related osteoporosis with current pathological fracture, left hand, subsequent encounter for fracture with nonunion
M80.042PAge-related osteoporosis with current pathological fracture, left hand, subsequent encounter for fracture with malunion
M80.042SAge-related osteoporosis with current pathological fracture, left hand, sequela
M80.051AAge-related osteoporosis with current pathological fracture, right femur, initial encounter for fracture
M80.051DAge-related osteoporosis with current pathological fracture, right femur, subsequent encounter for fracture with routine healing
M80.051GAge-related osteoporosis with current pathological fracture, right femur, subsequent encounter for fracture with delayed healing
M80.051KAge-related osteoporosis with current pathological fracture, right femur, subsequent encounter for fracture with nonunion
M80.051PAge-related osteoporosis with current pathological fracture, right femur, subsequent encounter for fracture with malunion
M80.051SAge-related osteoporosis with current pathological fracture, right femur, sequela
M80.052AAge-related osteoporosis with current pathological fracture, left femur, initial encounter for fracture
M80.052DAge-related osteoporosis with current pathological fracture, left femur, subsequent encounter for fracture with routine healing
M80.052GAge-related osteoporosis with current pathological fracture, left femur, subsequent encounter for fracture with delayed healing
M80.052KAge-related osteoporosis with current pathological fracture, left femur, subsequent encounter for fracture with nonunion
M80.052PAge-related osteoporosis with current pathological fracture, left femur, subsequent encounter for fracture with malunion
M80.052SAge-related osteoporosis with current pathological fracture, left femur, sequela
M80.061AAge-related osteoporosis with current pathological fracture, right lower leg, initial encounter for fracture
M80.061DAge-related osteoporosis with current pathological fracture, right lower leg, subsequent encounter for fracture with routine healing
M80.061GAge-related osteoporosis with current pathological fracture, right lower leg, subsequent encounter for fracture with delayed healing
M80.061KAge-related osteoporosis with current pathological fracture, right lower leg, subsequent encounter for fracture with nonunion
M80.061PAge-related osteoporosis with current pathological fracture, right lower leg, subsequent encounter for fracture with malunion
M80.061SAge-related osteoporosis with current pathological fracture, right lower leg, sequela
M80.062AAge-related osteoporosis with current pathological fracture, left lower leg, initial encounter for fracture
M80.062DAge-related osteoporosis with current pathological fracture, left lower leg, subsequent encounter for fracture with routine healing
M80.062GAge-related osteoporosis with current pathological fracture, left lower leg, subsequent encounter for fracture with delayed healing
M80.062KAge-related osteoporosis with current pathological fracture, left lower leg, subsequent encounter for fracture with nonunion
M80.062PAge-related osteoporosis with current pathological fracture, left lower leg, subsequent encounter for fracture with malunion
M80.062SAge-related osteoporosis with current pathological fracture, left lower leg, sequela
M80.071AAge-related osteoporosis with current pathological fracture, right ankle and foot, initial encounter for fracture
M80.071DAge-related osteoporosis with current pathological fracture, right ankle and foot, subsequent encounter for fracture with routine healing
M80.071GAge-related osteoporosis with current pathological fracture, right ankle and foot, subsequent encounter for fracture with delayed healing
M80.071KAge-related osteoporosis with current pathological fracture, right ankle and foot, subsequent encounter for fracture with nonunion
M80.071PAge-related osteoporosis with current pathological fracture, right ankle and foot, subsequent encounter for fracture with malunion
M80.071SAge-related osteoporosis with current pathological fracture, right ankle and foot, sequela
M80.072AAge-related osteoporosis with current pathological fracture, left ankle and foot, initial encounter for fracture
M80.072DAge-related osteoporosis with current pathological fracture, left ankle and foot, subsequent encounter for fracture with routine healing
M80.072GAge-related osteoporosis with current pathological fracture, left ankle and foot, subsequent encounter for fracture with delayed healing
M80.072KAge-related osteoporosis with current pathological fracture, left ankle and foot, subsequent encounter for fracture with nonunion
M80.072PAge-related osteoporosis with current pathological fracture, left ankle and foot, subsequent encounter for fracture with malunion
M80.072SAge-related osteoporosis with current pathological fracture, left ankle and foot, sequela
M80.08XAAge-related osteoporosis with current pathological fracture, vertebra(e), initial encounter for fracture
M80.08XDAge-related osteoporosis with current pathological fracture, vertebra(e), subsequent encounter for fracture with routine healing
M80.08XGAge-related osteoporosis with current pathological fracture, vertebra(e), subsequent encounter for fracture with delayed healing
M80.08XKAge-related osteoporosis with current pathological fracture, vertebra(e), subsequent encounter for fracture with nonunion
M80.08XPAge-related osteoporosis with current pathological fracture, vertebra(e), subsequent encounter for fracture with malunion
M80.08XSAge-related osteoporosis with current pathological fracture, vertebra(e), sequela
M80.0AXAAge-related osteoporosis with current pathological fracture, other site, initial encounter for fracture
M80.0AXDAge-related osteoporosis with current pathological fracture, other site, subsequent encounter for fracture with routine healing
M80.0AXGAge-related osteoporosis with current pathological fracture, other site, subsequent encounter for fracture with delayed healing
M80.0AXKAge-related osteoporosis with current pathological fracture, other site, subsequent encounter for fracture with nonunion
M80.0AXPAge-related osteoporosis with current pathological fracture, other site, subsequent encounter for fracture with malunion
M80.0AXSAge-related osteoporosis with current pathological fracture, other site, sequela
M80.0B1AAge-related osteoporosis with current pathological fracture, right pelvis, initial encounter for fracture
M80.0B1DAge-related osteoporosis with current pathological fracture, right pelvis, subsequent encounter for fracture with routine healing
M80.0B1GAge-related osteoporosis with current pathological fracture, right pelvis, subsequent encounter for fracture with delayed healing
M80.0B1KAge-related osteoporosis with current pathological fracture, right pelvis, subsequent encounter for fracture with nonunion
M80.0B1PAge-related osteoporosis with current pathological fracture, right pelvis, subsequent encounter for fracture with malunion
M80.0B1SAge-related osteoporosis with current pathological fracture, right pelvis, sequela
M80.0B2AAge-related osteoporosis with current pathological fracture, left pelvis, initial encounter for fracture
M80.0B2DAge-related osteoporosis with current pathological fracture, left pelvis, subsequent encounter for fracture with routine healing
M80.0B2GAge-related osteoporosis with current pathological fracture, left pelvis, subsequent encounter for fracture with delayed healing
M80.0B2KAge-related osteoporosis with current pathological fracture, left pelvis, subsequent encounter for fracture with nonunion
M80.0B2PAge-related osteoporosis with current pathological fracture, left pelvis, subsequent encounter for fracture with malunion
M80.0B2SAge-related osteoporosis with current pathological fracture, left pelvis, sequela
M80.811AOther osteoporosis with current pathological fracture, right shoulder, initial encounter for fracture
M80.811DOther osteoporosis with current pathological fracture, right shoulder, subsequent encounter for fracture with routine healing
M80.811GOther osteoporosis with current pathological fracture, right shoulder, subsequent encounter for fracture with delayed healing
M80.811KOther osteoporosis with current pathological fracture, right shoulder, subsequent encounter for fracture with nonunion
M80.811POther osteoporosis with current pathological fracture, right shoulder, subsequent encounter for fracture with malunion
M80.811SOther osteoporosis with current pathological fracture, right shoulder, sequela
M80.812AOther osteoporosis with current pathological fracture, left shoulder, initial encounter for fracture
M80.812DOther osteoporosis with current pathological fracture, left shoulder, subsequent encounter for fracture with routine healing
M80.812GOther osteoporosis with current pathological fracture, left shoulder, subsequent encounter for fracture with delayed healing
M80.812KOther osteoporosis with current pathological fracture, left shoulder, subsequent encounter for fracture with nonunion
M80.812POther osteoporosis with current pathological fracture, left shoulder, subsequent encounter for fracture with malunion
M80.812SOther osteoporosis with current pathological fracture, left shoulder, sequela
M80.821AOther osteoporosis with current pathological fracture, right humerus, initial encounter for fracture
M80.821DOther osteoporosis with current pathological fracture, right humerus, subsequent encounter for fracture with routine healing
M80.821GOther osteoporosis with current pathological fracture, right humerus, subsequent encounter for fracture with delayed healing
M80.821KOther osteoporosis with current pathological fracture, right humerus, subsequent encounter for fracture with nonunion
M80.821POther osteoporosis with current pathological fracture, right humerus, subsequent encounter for fracture with malunion
M80.821SOther osteoporosis with current pathological fracture, right humerus, sequela
M80.822AOther osteoporosis with current pathological fracture, left humerus, initial encounter for fracture
M80.822DOther osteoporosis with current pathological fracture, left humerus, subsequent encounter for fracture with routine healing
M80.822GOther osteoporosis with current pathological fracture, left humerus, subsequent encounter for fracture with delayed healing
M80.822KOther osteoporosis with current pathological fracture, left humerus, subsequent encounter for fracture with nonunion
M80.822POther osteoporosis with current pathological fracture, left humerus, subsequent encounter for fracture with malunion
M80.822SOther osteoporosis with current pathological fracture, left humerus, sequela
M80.831AOther osteoporosis with current pathological fracture, right forearm, initial encounter for fracture
M80.831DOther osteoporosis with current pathological fracture, right forearm, subsequent encounter for fracture with routine healing
M80.831GOther osteoporosis with current pathological fracture, right forearm, subsequent encounter for fracture with delayed healing
M80.831KOther osteoporosis with current pathological fracture, right forearm, subsequent encounter for fracture with nonunion
M80.831POther osteoporosis with current pathological fracture, right forearm, subsequent encounter for fracture with malunion
M80.831SOther osteoporosis with current pathological fracture, right forearm, sequela
M80.832AOther osteoporosis with current pathological fracture, left forearm, initial encounter for fracture
M80.832DOther osteoporosis with current pathological fracture, left forearm, subsequent encounter for fracture with routine healing
M80.832GOther osteoporosis with current pathological fracture, left forearm, subsequent encounter for fracture with delayed healing
M80.832KOther osteoporosis with current pathological fracture, left forearm, subsequent encounter for fracture with nonunion
M80.832POther osteoporosis with current pathological fracture, left forearm, subsequent encounter for fracture with malunion
M80.832SOther osteoporosis with current pathological fracture, left forearm, sequela
M80.841AOther osteoporosis with current pathological fracture, right hand, initial encounter for fracture
M80.841DOther osteoporosis with current pathological fracture, right hand, subsequent encounter for fracture with routine healing
M80.841GOther osteoporosis with current pathological fracture, right hand, subsequent encounter for fracture with delayed healing
M80.841KOther osteoporosis with current pathological fracture, right hand, subsequent encounter for fracture with nonunion
M80.841POther osteoporosis with current pathological fracture, right hand, subsequent encounter for fracture with malunion
M80.841SOther osteoporosis with current pathological fracture, right hand, sequela
M80.842AOther osteoporosis with current pathological fracture, left hand, initial encounter for fracture
M80.842DOther osteoporosis with current pathological fracture, left hand, subsequent encounter for fracture with routine healing
M80.842GOther osteoporosis with current pathological fracture, left hand, subsequent encounter for fracture with delayed healing
M80.842KOther osteoporosis with current pathological fracture, left hand, subsequent encounter for fracture with nonunion
M80.842POther osteoporosis with current pathological fracture, left hand, subsequent encounter for fracture with malunion
M80.842SOther osteoporosis with current pathological fracture, left hand, sequela
M80.851AOther osteoporosis with current pathological fracture, right femur, initial encounter for fracture
M80.851DOther osteoporosis with current pathological fracture, right femur, subsequent encounter for fracture with routine healing
M80.851GOther osteoporosis with current pathological fracture, right femur, subsequent encounter for fracture with delayed healing
M80.851KOther osteoporosis with current pathological fracture, right femur, subsequent encounter for fracture with nonunion
M80.851POther osteoporosis with current pathological fracture, right femur, subsequent encounter for fracture with malunion
M80.851SOther osteoporosis with current pathological fracture, right femur, sequela
M80.852AOther osteoporosis with current pathological fracture, left femur, initial encounter for fracture
M80.852DOther osteoporosis with current pathological fracture, left femur, subsequent encounter for fracture with routine healing
M80.852GOther osteoporosis with current pathological fracture, left femur, subsequent encounter for fracture with delayed healing
M80.852KOther osteoporosis with current pathological fracture, left femur, subsequent encounter for fracture with nonunion
M80.852POther osteoporosis with current pathological fracture, left femur, subsequent encounter for fracture with malunion
M80.852SOther osteoporosis with current pathological fracture, left femur, sequela
M80.861AOther osteoporosis with current pathological fracture, right lower leg, initial encounter for fracture
M80.861DOther osteoporosis with current pathological fracture, right lower leg, subsequent encounter for fracture with routine healing
M80.861GOther osteoporosis with current pathological fracture, right lower leg, subsequent encounter for fracture with delayed healing
M80.861KOther osteoporosis with current pathological fracture, right lower leg, subsequent encounter for fracture with nonunion
M80.861POther osteoporosis with current pathological fracture, right lower leg, subsequent encounter for fracture with malunion
M80.861SOther osteoporosis with current pathological fracture, right lower leg, sequela
M80.862AOther osteoporosis with current pathological fracture, left lower leg, initial encounter for fracture
M80.862DOther osteoporosis with current pathological fracture, left lower leg, subsequent encounter for fracture with routine healing
M80.862GOther osteoporosis with current pathological fracture, left lower leg, subsequent encounter for fracture with delayed healing
M80.862KOther osteoporosis with current pathological fracture, left lower leg, subsequent encounter for fracture with nonunion
M80.862POther osteoporosis with current pathological fracture, left lower leg, subsequent encounter for fracture with malunion
M80.862SOther osteoporosis with current pathological fracture, left lower leg, sequela
M80.871AOther osteoporosis with current pathological fracture, right ankle and foot, initial encounter for fracture
M80.871DOther osteoporosis with current pathological fracture, right ankle and foot, subsequent encounter for fracture with routine healing
M80.871GOther osteoporosis with current pathological fracture, right ankle and foot, subsequent encounter for fracture with delayed healing
M80.871KOther osteoporosis with current pathological fracture, right ankle and foot, subsequent encounter for fracture with nonunion
M80.871POther osteoporosis with current pathological fracture, right ankle and foot, subsequent encounter for fracture with malunion
M80.871SOther osteoporosis with current pathological fracture, right ankle and foot, sequela
M80.872AOther osteoporosis with current pathological fracture, left ankle and foot, initial encounter for fracture
M80.872DOther osteoporosis with current pathological fracture, left ankle and foot, subsequent encounter for fracture with routine healing
M80.872GOther osteoporosis with current pathological fracture, left ankle and foot, subsequent encounter for fracture with delayed healing
M80.872KOther osteoporosis with current pathological fracture, left ankle and foot, subsequent encounter for fracture with nonunion
M80.872POther osteoporosis with current pathological fracture, left ankle and foot, subsequent encounter for fracture with malunion
M80.872SOther osteoporosis with current pathological fracture, left ankle and foot, sequela
M80.88XAOther osteoporosis with current pathological fracture, vertebra(e), initial encounter for fracture
M80.88XDOther osteoporosis with current pathological fracture, vertebra(e), subsequent encounter for fracture with routine healing
M80.88XGOther osteoporosis with current pathological fracture, vertebra(e), subsequent encounter for fracture with delayed healing
M80.88XKOther osteoporosis with current pathological fracture, vertebra(e), subsequent encounter for fracture with nonunion
M80.88XPOther osteoporosis with current pathological fracture, vertebra(e), subsequent encounter for fracture with malunion
M80.88XSOther osteoporosis with current pathological fracture, vertebra(e), sequela
M80.8AXAOther osteoporosis with current pathological fracture, other site, initial encounter for fracture
M80.8AXDOther osteoporosis with current pathological fracture, other site, subsequent encounter for fracture with routine healing
M80.8AXGOther osteoporosis with current pathological fracture, other site, subsequent encounter for fracture with delayed healing
M80.8AXKOther osteoporosis with current pathological fracture, other site, subsequent encounter for fracture with nonunion
M80.8AXPOther osteoporosis with current pathological fracture, other site, subsequent encounter for fracture with malunion
M80.8AXSOther osteoporosis with current pathological fracture, other site, sequela
M81.0Age-related osteoporosis without current pathological fracture
M81.8Other osteoporosis without current pathological fracture

Neoplasms (29)

ICD-10Covered diagnosis
C50.011Malignant neoplasm of nipple and areola, right female breast
C50.012Malignant neoplasm of nipple and areola, left female breast
C50.111Malignant neoplasm of central portion of right female breast
C50.112Malignant neoplasm of central portion of left female breast
C50.211Malignant neoplasm of upper-inner quadrant of right female breast
C50.212Malignant neoplasm of upper-inner quadrant of left female breast
C50.311Malignant neoplasm of lower-inner quadrant of right female breast
C50.312Malignant neoplasm of lower-inner quadrant of left female breast
C50.411Malignant neoplasm of upper-outer quadrant of right female breast
C50.412Malignant neoplasm of upper-outer quadrant of left female breast
C50.511Malignant neoplasm of lower-outer quadrant of right female breast
C50.512Malignant neoplasm of lower-outer quadrant of left female breast
C50.611Malignant neoplasm of axillary tail of right female breast
C50.612Malignant neoplasm of axillary tail of left female breast
C50.811Malignant neoplasm of overlapping sites of right female breast
C50.812Malignant neoplasm of overlapping sites of left female breast
C50.911Malignant neoplasm of unspecified site of right female breast
C50.912Malignant neoplasm of unspecified site of left female breast
C50.A1Malignant inflammatory neoplasm of right breast
C50.A2Malignant inflammatory neoplasm of left breast
C61Malignant neoplasm of prostate
D05.01Lobular carcinoma in situ of right breast
D05.02Lobular carcinoma in situ of left breast
D05.11Intraductal carcinoma in situ of right breast
D05.12Intraductal carcinoma in situ of left breast
D05.81Other specified type of carcinoma in situ of right breast
D05.82Other specified type of carcinoma in situ of left breast
D05.91Unspecified type of carcinoma in situ of right breast
D05.92Unspecified type of carcinoma in situ of left breast

Factors influencing health status (11)

ICD-10Covered diagnosis
Z48.816Encounter for surgical aftercare following surgery on the genitourinary system
Z51.89Encounter for other specified aftercare
Z79.810Long term (current) use of selective estrogen receptor modulators (SERMs)
Z79.811Long term (current) use of aromatase inhibitors
Z79.818Long term (current) use of other agents affecting estrogen receptors and estrogen levels
Z79.899Other long term (current) drug therapy
Z85.3Personal history of malignant neoplasm of breast
Z85.46Personal history of malignant neoplasm of prostate
Z86.000Personal history of in-situ neoplasm of breast
Z88.8Allergy status to other drugs, medicaments and biological substances
Z92.29Personal history of other drug therapy

Injury, poisoning & external causes (2)

ICD-10Covered diagnosis
T50.995SAdverse effect of other drugs, medicaments and biological substances, sequela
T88.7XXSUnspecified adverse effect of drug or medicament, sequela

How to use this list when billing

Put the patient's covered ICD-10 diagnosis on the claim line with J0897 and confirm your documentation supports medical necessity. Match the right product code (reference vs biosimilar) and units, and check the diagnosis against the article for your MAC, since the list above is National Government Services, Inc. policy.

LCD vs. Billing & Coding Article vs. NCD

An LCD (Local Coverage Determination) is a MAC's policy on whether a service is reasonable and necessary in its region, and its companion Billing & Coding Article holds the covered ICD-10 and HCPCS code lists. A NCD (National Coverage Determination), where one exists, applies nationwide. For Denosumab (Prolia, Xgeva), the code lists live in Article A52399 (tied to LCD L33394) — CMS moved code lists out of LCDs and into Articles, which is why the diagnoses live in the Article, not the LCD.

Common Denosumab (Prolia, Xgeva) denial reasons

What you seeWhyFix
CO-50 — not medically necessaryDiagnosis not in the covered list for J0897Bill a covered ICD-10 from the groups above, or document an exception
Diagnosis/units mismatchRight dx but wrong product code or unit countMatch the J/Q code and units to the drug actually given (check JZ/JW wastage)
Covered by one MAC, denied by anotherYou used a different region's covered listUse the Article for your MAC (coverage varies)
Non-covered / statutorily excluded dxDiagnosis is on the non-covered listConfirm against the Article's non-covered ICD-10 group

Frequently asked questions

Is Denosumab (Prolia, Xgeva) covered by Medicare?
Yes. Denosumab (Prolia, Xgeva) (J0897) is covered under Medicare Part B as a physician-administered drug when billed for a medically necessary, covered diagnosis. Local coverage is defined by National Government Services, Inc. in Billing & Coding Article A52399, tied to LCD L33394.
What diagnoses are covered for Denosumab (Prolia, Xgeva) (J0897)?
Medicare lists 409 covered ICD-10 diagnosis codes for J0897 under Article A52399. The full list is on this page, grouped by condition category. Coverage can vary by Medicare Administrative Contractor (MAC); confirm against the article that applies in your state.
Which Medicare policy covers Denosumab (Prolia, Xgeva)?
Billing & Coding Article A52399 (v71), tied to LCD L33394 (“Drugs and Biologicals, Coverage of, for Label and Off-Label Uses”), published by National Government Services, Inc. and last updated 03/27/2026.
Why was my Denosumab (Prolia, Xgeva) claim denied as not medically necessary?
The most common cause is an ICD-10 diagnosis on the claim that is not in the covered list for J0897. Confirm the patient's diagnosis is in the groups below, that documentation supports medical necessity, and that you are using the article for your MAC.

Related references

Covered is only half the answer.

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Source & verification

Source
CMS Medicare Coverage Database — Billing & Coding Article A52399 (v71), LCD L33394 “Drugs and Biologicals, Coverage of, for Label and Off-Label Uses” — National Government Services, Inc..
CMS article last revised
03/27/2026 — the most recent revision CMS has published for this article.
Page last reviewed by CareCost
Jun 29, 2026 (coverage data retrieved 2026-06-28; we re-verify against CMS quarterly).
Code licensing
ICD-10-CM codes are public domain (CMS/CDC). CPT® codes are AMA-copyrighted and are intentionally not listed here — see the administration-code reference for those.
Not advice
This is general billing reference, not legal or billing advice. Always verify against the LCD/Article that applies to your MAC and patient.
How we build this
Compiled programmatically from the CMS Coverage API and reviewed by the CareCost Estimate editorial team against the source article. See our methodology and editorial policy.
Spotted an error?
Email editorial@carecostestimate.com.