CareCost Syringes
1 × 3.75 mg kit
1 billing unit = 3.75 mg
3.75 mg 1-month kit → 1 unit · 11.25 mg 3-month kit → 3 units
J1950 · leuprolide acetate
Single-dose dual-chamber syringe kit, reconstituted at the visit · JZ on every claim
Calculate this patient's units ↓3.75 mg IM once a month (1-month kit) or 11.25 mg IM once every 3 months (3-month kit) · one kit per visit
This Lupron Depot claim carries straight into Claim Check.
Claim Check builds the whole visit — J1950 units, the administration line, the modifiers and the Medicare allowed amount — and prices it against your payer's rate. The estimate turns the same visit into what the patient owes.
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Patient owes, 3.75 mg
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37 payer price files · Commercial + Medicare · Copay and foundation status · Deductible, coinsurance and out-of-pocket math
Lupron Depot J1950 is billed in units of 3.75 mg: ordered dose ÷ 3.75 mg = billing units. The gynecology kits come in two labeled sizes, not a continuous dose range, so the calculation only ever lands on one of two answers: 3.75 mg ÷ 3.75 mg = 1 unit for the 1-month kit, and 11.25 mg ÷ 3.75 mg = 3 units for the 3-month kit.
Each kit ships as a single-dose dual-chamber syringe, reconstituted with its own diluent at the visit and used within two hours of mixing, so the amount drawn equals the amount administered with nothing left over. That is why JZ is the modifier on every Lupron Depot claim; there is no per-kit waste math to do.
Medicare pays $1,799.052 per 3.75 mg unit (ASP+6%), effective for claims in Q4 2026 —
$1,799.05 for the 1-unit kit and $5,397.16 for the 3-unit kit.
| Kit | HCPCS | Dose | Billing units |
|---|---|---|---|
| 1-month kit | J1950 | 3.75 mg | 1 |
| 3-month kit | J1950 | 11.25 mg | 3 |
Both kits bill the same code, J1950, at 1 unit per 3.75 mg. The unit count on the claim is what tells a payer which kit was given. There is no third gynecology strength: a patient on the 1-month kit gets 1 unit once a month, and a patient on the 3-month kit gets 3 units once every 3 months, never a fractional or in-between count.
JZ — no discarded drug from the single-dose kit. CMS's July 1, 2023 single-dose container policy requires JW or JZ on every J1950 claim; Lupron Depot's kits carry JZ.
J1950 × 1 JZ · 96372 × 1.
J1950 × 3 JZ · 96372 × 1. MUE J1950 is 12 units per day, so neither kit approaches it; a claim entered as 11.25 units instead of 3 also stays under it, so the edit will not catch that error.
There is no JW section for Lupron Depot: each kit is a single-dose dual-chamber syringe reconstituted at the visit and given whole, so there is never drug left over to discard.
96372 covers a therapeutic, prophylactic, or diagnostic injection given subcutaneously or intramuscularly. Lupron Depot's gynecology kits are given IM and billed with 96372 alone — there is no infusion time to report, so the infusion-administration codes (96413 initial hour, 96415 each additional hour) used by IV biologics do not apply. The gynecology kits are also not an anti-neoplastic use, so 96402 (hormonal anti-neoplastic injection) does not apply either; that code, paired with J9217 instead of J1950, belongs to the same brand's prostate-cancer strengths (7.5 to 45 mg), a different product on a different code. The visit itself typically runs about 15 minutes, including reconstitution of the kit.
Lupron Depot is supplied as two single-dose dual-chamber syringe kits, each with a chamber of white lyophilized leuprolide acetate microspheres and a chamber of diluent: the 3.75 mg kit (NDC 0074-3641-03, 1 mL diluent) and the 11.25 mg kit (NDC 0074-3663-03, 1.5 mL diluent). Reconstitute at the visit and use within two hours of mixing; there is no vial to draw from and no other kit size. See the FDA Lupron Depot label (NDA 020011, AbbVie) for full dosing and administration instructions.
J1950 also covers Lupron Depot-Ped, the same brand's central precocious puberty formulation, which is not part of the coverage corpus these pages read. The brand's higher-strength prostate-cancer kits (7.5, 22.5, 30 and 45 mg) bill a different code, J9217, per 7.5 mg, with 96402 rather than 96372. Other GnRH-agonist and depot products bill their own codes: Eligard (Tolmar) also under J9217; Fensolvi (leuprolide acetate, pediatric, Tolmar) under J1951; Camcevi (leuprolide mesylate, Accord BioPharma) under J1952; Zoladex (goserelin acetate implant, TerSera) under J9202; and Trelstar (triptorelin pamoate, Verity) under J3315. See the HCPCS hub for coding across the full family. The Medicare rate for every quarter is on the cost page →
3 billing units. Lupron Depot J1950 bills 1 unit per 3.75 mg, and the 11.25 mg 3-month kit is three times the 1-month kit, so it is billed as 3 units on one line. Billing it as 1 unit under-reports the drug by two-thirds; billing 11.25 units over-reports it threefold.
J1950, billed per 3.75 mg, for the gynecology kits used in endometriosis and preoperative anemia from fibroids. The same brand's prostate-cancer strengths, 7.5 mg to 45 mg, bill a different code, J9217, per 7.5 mg, with 96402 instead of 96372.
JZ on every claim. Each kit is a single-dose dual-chamber syringe reconstituted at the visit and given as one injection, so nothing is left over to discard. JW never applies to Lupron Depot.
No. Lupron Depot is an intramuscular injection billed with 96372, not an infusion
administration code. There is no infusion time to report, so 96413 and 96415
do not apply, and because the gynecology kits are not an anti-neoplastic use, neither does
96402, the code the prostate-cancer strengths bill under J9217.
Billing the 11.25 mg 3-month kit as 1 unit instead of 3, or billing 11.25 units instead of 3, since J1950 is measured in units of 3.75 mg rather than milligrams.
Once a month for the 3.75 mg kit or once every 3 months for the 11.25 mg kit, one kit per visit. The label caps the course at 6 months for endometriosis (retreatment only with norethindrone acetate add-back, 12 months lifetime) and 3 months before fibroid surgery, so it is not billed as ongoing maintenance.
$1,799.052 per 3.75 mg unit (ASP+6%), effective for claims in Q4 2026, which prices the 1-unit kit at $1,799.05 and the 3-unit kit at $5,397.16.
12 units per day (MAI 3, clinical). The 3-unit 11.25 mg kit is nowhere near that limit, and a claim billed at 11.25 units instead of 3 stays under it too, so the edit does not catch that error.
Data current: pricing Q4 2026 · payer policies Aug 2026
Sources: CMS ASP pricing files (Q4 2026); Medicare physician fee schedule (96372, national non-facility); FDA-approved prescribing information (Lupron Depot 3.75 mg and 11.25 mg labels, AbbVie, NDA 020011 / 020708); CMS single-dose container JW/JZ policy (effective July 1, 2023); CMS MUE table (J1950, 12 units/day); CPT codebook administration-code guidance; the leuprolide_acetate coverage corpus (20 commercial payer medical policies) in the CareCost Clearance database.
Reviewed September 20, 2026 by Erin Rose, CareCost Estimate founder. Methodology →