CareCost Vials
2 × 500 mg
1 billing unit = 10 mg
1,000 mg dose → 100 billing units
J9312 · rituximab
100 mg/10 mL and 500 mg/50 mL single-dose vials · JZ for the standard dose
Calculate this patient's units ↓Typical Rituxan RA dose: 1,000 mg (flat, not weight-based)
This Rituxan claim carries straight into Claim Check.
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Patient owes, 1,000 mg
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37 payer price files · Commercial + Medicare · Copay and foundation status · Deductible, coinsurance and out-of-pocket math
Rituxan J9312 is billed in units of 10 mg: ordered dose ÷ 10 mg = billing units. The rheumatoid arthritis dose the label states is flat, not weight-based: two 1,000 mg infusions two weeks apart make up one course, repeated every 24 weeks and not sooner than every 16 weeks, with methotrexate. Example: 1,000 mg ÷ 10 mg = 100 billing units.
Multiply the dose in mg by 1 unit per 10 mg, then round up to the next whole unit (1 unit = 10 mg). The 1,000 mg dose draws two 500 mg vials with nothing discarded, so the claim carries JZ, never JW. A 375 mg/m² body-surface-area dose, used for the granulomatosis with polyangiitis and microscopic polyangiitis induction regimens, is patient-specific and is not priced on this page.
Medicare pays $72.094 per billing unit (ASP+6%, per 10 mg), effective for claims in
Q4 2026, which is $7,209.40 for the 100-unit rheumatoid-arthritis example above.
| Dose | Billing units |
|---|---|
| 100 mg | 10 |
| 200 mg | 20 |
| 300 mg | 30 |
| 400 mg | 40 |
| 500 mg | 50 |
| 600 mg | 60 |
| 700 mg | 70 |
| 800 mg | 80 |
| 900 mg | 90 |
| 1,000 mg | 100 |
Medicare’s medically unlikely edit for J9312 is 150 units (1,500 mg) a day, with an MAI of 3 — a date-of-service edit, so a claim over the limit is denied rather than cut back. The 1,000 mg rheumatoid-arthritis dose is 100 units, well inside it; a 375 mg/m² dose for a large patient can approach it.
JZ — no discarded drug from a single-dose container. JW — discarded drug from a single-dose container, reported on its own claim line.
J9312 × 100 JZ · 96413 × 1 · 96415 × 3.
J9312 × 50 JZ.
96413 covers the initial hour of a chemotherapy/complex-biologic infusion; 96415 is an add-on for each additional hour. Rituximab is billed under this code family as a complex biologic agent administration. The label's infusion rate starts at 50 mg/hr on the first infusion, escalating by 50 mg/hr every 30 minutes to 400 mg/hr, and starts at 100 mg/hr on later infusions, so the 1,000 mg rheumatoid-arthritis infusion runs about four hours: 96413 × 1 and 96415 × 3. Payers that treat a non-oncology rituximab infusion as a therapeutic infusion instead require 96365 and 96366; the site's catalog rows for Truxima, Ruxience and Riabni carry those codes. Methylprednisolone 100 mg IV, or an equivalent glucocorticoid, given 30 minutes before each RA infusion is billed as its own drug line, not part of the rituximab units.
Rituxan is supplied as two single-dose vials, 100 mg/10 mL and 500 mg/50 mL, both a 10 mg/mL solution, already liquid rather than a lyophilized powder. The larger vial covers the flat 1,000 mg rheumatoid-arthritis dose (two 500 mg vials); the smaller vial covers the 500 mg maintenance doses used in granulomatosis with polyangiitis, microscopic polyangiitis and pemphigus vulgaris. Dilute the drawn volume into the infusion bag before administering. Genentech NDC for Rituxan: 50242-051-21 (100 mg/10 mL) and 50242-053-06 (500 mg/50 mL). See the FDA Rituxan label (BLA 103705) for the full dilution and administration instructions.
J9312 is the reference-product code for Rituxan; three biosimilar Q-codes cover the rest of the rituximab family: Truxima (Q5115), Ruxience (Q5119) and Riabni (Q5123), each billed under its own HCPCS and its own ASP rather than J9312. Rituxan Hycela, the subcutaneous formulation, carries its own code (J9311) and its own fixed doses, and is not interchangeable with an IV order. See the HCPCS hub for coding across the full family. The Medicare rate for every quarter is on the cost page →
10 billing units.
50 billing units.
J9312.
Use JZ when no drug is discarded from the single-dose container. Use JW, on its own line, for the discarded amount. The standard 1,000 mg rheumatoid arthritis dose draws two 500 mg vials with nothing discarded, so that claim carries JZ.
100 billing units. The label's rheumatoid arthritis dose is a flat 1,000 mg, not weight-based, given as two 1,000 mg infusions two weeks apart, repeated every 24 weeks and not sooner than every 16 weeks, with methotrexate.
No. The 375 mg/m2 induction dose used for granulomatosis with polyangiitis and microscopic polyangiitis is based on body surface area, which is patient-specific; this page and its calculator price a flat mg dose only.
Rituximab administration is billed with 96413 (initial hour) and 96415 (each additional hour), the codes CPT designates for chemotherapy and other complex drug or biologic administration. The 1,000 mg rheumatoid arthritis infusion runs about four hours: 96413 × 1 and 96415 × 3. Some payers instead require the non-chemotherapy codes 96365 and 96366; follow the payer's policy.
$72.094 per billing unit (ASP+6%, per 10 mg), effective for claims in Q4 2026.
Data current: pricing Q4 2026 · payer policies Aug 2026
Sources: CMS ASP pricing files (Q4 2026); manufacturer prescribing information (Genentech, Teva/Celltrion, Pfizer, Amgen, 2025–2026); 25 commercial payer medical policies verified Aug 2026; CPT codebook administration-code guidance.
Reviewed September 22, 2026 by Erin Rose, CareCost Estimate founder. Methodology →