INFeD (iron dextran) — HCPCS J1750

CareCost Estimate · Billing Cheat Sheet

Allergan / AbbVie 100 mg / 2 mL single-dose vial (LMW iron dextran) IDA when oral iron is unsatisfactory or impossible Reviewed: May 2, 2026 ASP: Q2 2026

HCPCS — UNIT TRAP

J1750

1 unit = 50 mg (NOT 1 mg)

Test dose

REQUIRED

25 mg slow IV + observe ≥1 hr

100 mg dose

2 units

1 vial · bill 2 units, not 100

Admin CPT

96374

+ 96365 for therapeutic infusion

Medicare ASP+6%

$18.105

/50 mg unit · ~$0.362/mg

BOXED WARNING — serious hypersensitivity / anaphylaxis (sometimes fatal). Reactions can occur even after a tolerated test dose and even in patients who have previously tolerated INFeD. Administer only by healthcare professionals trained to recognize and manage anaphylaxis with resuscitation equipment + epinephrine immediately available.

Codes & NDC

HCPCS	`J1750` — "Inj iron dextran, 50 mg" (legacy descriptor; 1 unit = 50 mg, not 1 mg)
NDC	`0023-6082-10` / `00023-6082-10` (Allergan/AbbVie) — verify carton on hand; N4 qualifier
Vial	100 mg / 2 mL (50 mg/mL elemental iron) single-dose
Class	Low molecular weight (LMW) iron dextran. Only iron dextran in US. DexFerrum (HMW) withdrawn 2009.
Benefit	Medical (provider buy-and-bill)

Dosing — Ganzoni-driven

Total iron mg = body weight (kg) × (Hgb target − Hgb actual) × 2.4 + iron stores
Typical adult Ganzoni course: 500–2,000 mg cumulative
Per session: typically ≤100 mg (1 vial), IV infusion or slow IV push
TDI (off-label): single 4–6 hour session; requires extended observation
Pediatric ≥4 mo: weight-based; test dose 0.025 mL/kg (max 25 mg)

UNIT MATH: mg ÷ 50 = units. 100 mg = 2 units. 500 mg = 10 units. 1,000 mg = 20 units. NEVER key mg as units.

Test dose protocol — required every course

Volume: 0.5 mL (25 mg) IV slow injection over ≥30 seconds
Observation: ≥1 hour with full resuscitation capability on hand
Repeat: at every new course of therapy — not waivable on rechallenge
Document: admin time, observation duration, vital sign trend, reaction status
Bill: 96374 for the test dose IV push; J1750 line for units administered + JW for waste

Administration & modifiers

Code	When
`96374`	Test dose (slow IV push) — primary admin code at first session
`96365`	Therapeutic IV infusion, up to 1 hour (subsequent sessions)
`96366`	Each additional hour (TDI 4–6 hr protocols)
`96413`	Not appropriate — INFeD is non-chemo
JZ: full vial used, no waste. JW: partial-vial waste (test dose 75 mg discard, pediatric, sub-100 mg sessions). One must be on every claim.

IV iron class comparison

Brand	HCPCS	Unit	Test dose	Boxed
INFeD	`J1750`	50 mg	YES	YES
Injectafer	`J1439`	1 mg	No	No (hypoP W&P)
Monoferric	`J1437`	1 mg	No	No
Feraheme	`Q0138`	1 mg	No	YES
Venofer	`J1756`	1 mg	No	No

Last-line in modern algorithms. Boxed Warning + test dose + multi-session pattern means most payers/sites now prefer non-dextran IV irons first.

ICD-10 — IDA (primary)

Code	For
`D50.0`	IDA secondary to chronic blood loss (GI, GU, menorrhagia)
`D50.8`	Other iron deficiency anemias
`D50.9`	IDA, unspecified
`D62`	Acute posthemorrhagic anemia
`D64.9`	Anemia, unspecified (pair with workup)

ICD-10 — CKD anemia + pregnancy

Code	For
`N18.1–N18.5`	CKD stages 1-5 (NDD); not labeled but covered when paired with D63.1
`D63.1`	Anemia in CKD (pair with N18.x)
`O99.011–013`	Anemia complicating pregnancy (1st/2nd/3rd tri) — pair with D50.x
`N18.6`	NO — ESRD/dialysis bundled; use Venofer/Feraheme

Payer requirements (May 2026)

Payer	PA	Step / Preference
UnitedHealthcare	Yes	Step through Injectafer/Monoferric/Feraheme typically required
Aetna	Yes	Non-dextran step therapy; INFeD on documented intolerance
BCBS plans	Yes	Plan-specific; many treat INFeD as last-line; pregnancy IDA exception at some
Medicare (MAC LCDs)	No (PA)	Documentation expected; test dose chart record

PA pathway: document oral iron failure + at least one non-dextran IV iron failure or intolerance. Submit prior product, dose, dates, reason.

Medicare reimbursement (Q2 2026)

Field	Value
ASP + 6%	$18.105 / 50 mg unit (~$0.362/mg, eff. 4/1 – 6/30/2026)
100 mg dose (1 vial)	$36.21 (2 units × $18.105)
1,000 mg cumulative course	$362.10 (20 units × ASP+6%)
vs Injectafer J1439	$1.103/mg — INFeD is ~3× cheaper per mg but higher admin volume

Site of care

Setting	POS	Notes
Physician office	11	Only with crash-cart capability + trained staff
Ambulatory infusion suite	49	Common; verify resuscitation readiness
Hospital outpatient	22 / 19	Often preferred for first INFeD course
Patient home	12	Generally inappropriate — Boxed Warning

Patient assistance — Allergan / AbbVie

myAbbVie Assist: general AbbVie patient assistance — verify INFeD coverage at enrollment
INFeD-specific public-facing program: limited; verify directly with Allergan/AbbVie patient services
Foundations: PAN, HealthWell, NeedyMeds for IDA — verify open funds quarterly
Lower per-mg drug cost means lower OOP exposure even before assistance, but multi-session coinsurance can still be material

DOUBLE-CHECK BEFORE CLAIM SUBMIT: (1) Units = mg ÷ 50, NOT mg as units. (2) Test dose documented in chart for new course. (3) JZ on full-vial encounter, JW on partial-vial encounter. (4) 96374 for test dose, 96365 for therapeutic infusion, never 96413.

Sources: FDA INFeD label (Boxed Warning + test dose protocol), Allergan/AbbVie product info, CMS ASP Q2 2026, UHC/Aetna IV iron LCDs, KDIGO IDA / ACG IDA guidelines, FDA market withdrawal notice (DexFerrum 2009). carecostestimate.com/drugs/infed