:root{--ocr-blue: #1D4ED8;--ocr-blue-deep: #1E3A8A;--ocr-deep: #0F2440;--ocr-border: #E2E8F0;--ocr-soft: #F8FAFC;--ocr-soft2: #EEF2F7;--ocr-text: #0F172A;--ocr-mute: #64748B;--ocr-good: #047857;--ocr-good-bg: #ECFDF5;--ocr-warn: #B45309;--ocr-warn-bg: #FFFBEB;--ocr-bad: #B91C1C;--ocr-bad-bg: #FEF2F2}.drug-hero{background:linear-gradient(135deg,var(--ocr-deep) 0%,#1E3A5F 60%,var(--ocr-blue) 100%);color:#fff;padding:28px 0 22px}.drug-hero .container{max-width:1080px;margin:0 auto;padding:0 24px}.drug-hero .breadcrumb{font-size:12px;color:#ffffffb3;margin-bottom:8px;letter-spacing:.02em}.drug-hero .breadcrumb a{color:#ffffffd9;text-decoration:none}.drug-hero .breadcrumb a:hover{text-decoration:underline}.drug-hero h1{color:#fff;font-size:32px;line-height:1.15;font-weight:800;margin:0 0 4px;letter-spacing:-.015em}.drug-hero .brand-line{font-size:14px;color:#ffffffd9;margin:0 0 12px}.drug-hero .hero-summary{font-size:14px;color:#ffffffeb;line-height:1.55;max-width:820px;margin:0;border-top:1px solid rgba(255,255,255,.18);padding-top:12px}.drug-hero .hero-summary strong{color:#fff;font-weight:700}.freshness-ribbon{max-width:1080px;margin:0 auto;padding:0 24px}.freshness-ribbon-inner{background:linear-gradient(90deg,#f0fdf4,#f0f9ff);border:1px solid #BBF7D0;border-radius:0 0 10px 10px;border-top:none;padding:8px 14px;display:flex;flex-wrap:wrap;gap:6px 18px;font-size:12px;color:#14532d}.freshness-ribbon .item{display:flex;gap:6px;align-items:center;white-space:nowrap}.freshness-ribbon .check{display:inline-block;width:14px;height:14px;border-radius:50%;background:var(--ocr-good);color:#fff;font-size:10px;font-weight:800;line-height:14px;text-align:center;flex-shrink:0}.freshness-ribbon .label{color:var(--ocr-mute);font-weight:600;letter-spacing:.02em}.freshness-ribbon .value{color:#14532d;font-weight:600}.factcard-wrap{max-width:1080px;margin:16px auto 0;padding:0 24px}.factcard{background:#fff;border:1px solid var(--ocr-border);border-radius:14px;box-shadow:0 14px 40px #0f172a14;padding:22px 22px 18px}.factcard h2{font-size:11px;font-weight:800;letter-spacing:.14em;text-transform:uppercase;color:var(--ocr-blue);margin:0 0 14px}.tier1{display:grid;grid-template-columns:repeat(5,1fr);gap:10px;margin-bottom:18px}.tier1 .cell{border:1px solid var(--ocr-border);border-radius:10px;padding:12px 14px;background:var(--ocr-soft)}.tier1 .cap{font-size:10px;font-weight:800;letter-spacing:.12em;text-transform:uppercase;color:var(--ocr-mute);margin-bottom:4px}.tier1 .big{font-size:24px;font-weight:800;color:var(--ocr-text);font-family:SF Mono,Menlo,Consolas,monospace;letter-spacing:-.01em;line-height:1.15}.tier1 .big.text{font-family:inherit;font-size:22px}.tier1 .sub{font-size:12px;color:var(--ocr-mute);margin-top:3px}.tier2{border:1px solid var(--ocr-border);border-radius:10px;overflow:hidden;margin-bottom:16px}.tier2 .row{display:grid;grid-template-columns:180px 1fr;font-size:13px;border-bottom:1px solid var(--ocr-border)}.tier2 .row:last-child{border-bottom:none}.tier2 .row .k{background:var(--ocr-soft);padding:9px 14px;font-weight:600;color:var(--ocr-mute);letter-spacing:.02em}.tier2 .row .v{padding:9px 14px;color:var(--ocr-text)}.tier2 code{font-family:SF Mono,Menlo,Consolas,monospace;font-size:12px;background:#f1f5f9;padding:1px 6px;border-radius:4px}.tier2 .pill{display:inline-block;font-size:10px;font-weight:700;padding:1px 7px;border-radius:999px;vertical-align:middle;background:var(--ocr-good-bg);color:var(--ocr-good);letter-spacing:.04em;text-transform:uppercase}.tier3{display:flex;gap:10px;flex-wrap:wrap}.tier3 .btn{display:inline-block;padding:10px 16px;border-radius:8px;font-weight:600;font-size:14px;text-decoration:none}.tier3 .btn-primary{background:var(--ocr-blue);color:#fff}.tier3 .btn-primary:hover{background:var(--ocr-blue-deep)}.tier3 .btn-ghost{background:#fff;color:var(--ocr-blue);border:1px solid var(--ocr-blue)}.tier3 .btn-ghost:hover{background:#eff6ff}.variant-callout{max-width:1080px;margin:14px auto 0;padding:0 24px}.variant-callout-inner{background:#eff6ff;border:1px solid #BFDBFE;border-radius:10px;padding:12px 16px;font-size:13px;color:var(--ocr-blue-deep);display:flex;gap:12px;align-items:flex-start}.variant-callout-inner .icon{font-size:16px;line-height:1.2;flex-shrink:0}.variant-callout-inner a{color:var(--ocr-blue);font-weight:600}.toc-mobile{display:none;position:sticky;top:56px;z-index:40;background:#fff;border-bottom:1px solid var(--ocr-border);box-shadow:0 2px 8px #0f172a0f}.toc-mobile-trigger{width:100%;padding:10px 24px;background:#fff;border:none;cursor:pointer;font-size:13px;font-weight:600;color:var(--ocr-text);display:flex;justify-content:space-between;align-items:center}.toc-mobile-trigger .arrow{transition:transform .15s;font-size:11px}.toc-mobile.open .arrow{transform:rotate(180deg)}.toc-mobile-panel{display:none;max-height:70vh;overflow-y:auto;background:#fff;border-top:1px solid var(--ocr-border);padding:8px 0}.toc-mobile.open .toc-mobile-panel{display:block}.toc-mobile-panel ul{list-style:none;margin:0;padding:0}.toc-mobile-panel li{padding:0}.toc-mobile-panel a{display:block;padding:8px 24px;font-size:13px;color:var(--ocr-text);text-decoration:none}.toc-mobile-panel a.phase{font-weight:700;color:var(--ocr-blue);font-size:11px;text-transform:uppercase;letter-spacing:.12em;background:var(--ocr-soft);padding-top:10px;padding-bottom:6px;pointer-events:none}.drug-body{max-width:1080px;margin:0 auto;padding:36px 24px 64px;display:grid;grid-template-columns:240px minmax(0,1fr);gap:56px}.drug-body main{min-width:0}.drug-body section{scroll-margin-top:24px}.drug-body section+section{margin-top:36px}.drug-body h2{font-size:22px;font-weight:800;color:var(--ocr-text);letter-spacing:-.01em;margin:0 0 6px}.drug-body .h2-sub{font-size:13px;color:var(--ocr-mute);margin:0 0 14px}.drug-body h3{font-size:16px;font-weight:700;color:var(--ocr-text);margin:18px 0 6px}.drug-body p{font-size:15px;line-height:1.6;color:var(--ocr-text)}.drug-body ul{font-size:15px;line-height:1.6;color:var(--ocr-text);padding-left:22px}.drug-body code{font-family:SF Mono,Menlo,Consolas,monospace;font-size:13px;background:#f1f5f9;padding:1px 6px;border-radius:4px}.section-stamp{display:inline-block;font-size:11px;color:var(--ocr-mute);background:var(--ocr-soft);border:1px solid var(--ocr-border);padding:2px 8px;border-radius:999px;letter-spacing:.02em;vertical-align:middle;margin-left:8px;font-weight:500}.phase-marker{margin:48px 0 20px;padding-bottom:8px;border-bottom:2px solid var(--ocr-border);display:flex;align-items:baseline;gap:12px}.phase-marker .num{font-size:11px;font-weight:800;letter-spacing:.14em;color:var(--ocr-blue);text-transform:uppercase}.phase-marker .name{font-size:18px;font-weight:700;color:var(--ocr-text)}.phase-marker .desc{font-size:13px;color:var(--ocr-mute);margin-left:auto}.drug-body section:first-of-type~.phase-marker:first-of-type{margin-top:0}.drug-toc{position:sticky;top:24px;align-self:start;font-size:13px}.drug-toc h4{font-size:11px;font-weight:800;letter-spacing:.14em;text-transform:uppercase;color:var(--ocr-mute);margin:0 0 10px}.drug-toc .toc-phase{font-size:11px;font-weight:800;letter-spacing:.14em;color:var(--ocr-blue);text-transform:uppercase;margin:16px 0 6px}.drug-toc .toc-phase:first-child{margin-top:0}.drug-toc ul{list-style:none;padding:0;margin:0}.drug-toc li{margin-bottom:4px}.drug-toc a{color:var(--ocr-text);text-decoration:none;border-left:2px solid var(--ocr-border);padding-left:10px;display:block;line-height:1.4}.drug-toc a:hover{color:var(--ocr-blue);border-left-color:var(--ocr-blue)}.table-wrap{overflow-x:auto;border:1px solid var(--ocr-border);border-radius:10px;margin:12px 0 8px;position:relative;-webkit-overflow-scrolling:touch;background:linear-gradient(to right,#fff 30%,#fff0),linear-gradient(to right,#fff0,#fff 70%) 100% 0,radial-gradient(farthest-side at 0 50%,#0f172a1a,#fff0),radial-gradient(farthest-side at 100% 50%,#0f172a1a,#fff0) 100% 0;background-repeat:no-repeat;background-size:30px 100%,30px 100%,14px 100%,14px 100%;background-attachment:local,local,scroll,scroll}.drug-table{width:100%;border-collapse:collapse;font-size:14px}.drug-table th{background:var(--ocr-soft);text-align:left;padding:9px 12px;font-weight:600;color:var(--ocr-mute);font-size:11px;letter-spacing:.04em;text-transform:uppercase;border-bottom:1px solid var(--ocr-border);white-space:nowrap}.drug-table td{padding:9px 12px;border-bottom:1px solid var(--ocr-border);color:var(--ocr-text);vertical-align:top;min-width:100px}.drug-table tr:last-child td{border-bottom:none}.drug-table .num{font-variant-numeric:tabular-nums;white-space:nowrap}.callout{border-left:4px solid var(--ocr-blue);background:#eff6ff;padding:12px 14px;border-radius:0 8px 8px 0;margin:14px 0;font-size:14px;color:var(--ocr-blue-deep);line-height:1.55}.callout.warn{border-left-color:#d97706;background:var(--ocr-warn-bg);color:#78350f}.callout.danger{border-left-color:#dc2626;background:var(--ocr-bad-bg);color:#7f1d1d}.callout strong{color:inherit}.math-block{background:#0f172a;color:#e2e8f0;font-family:SF Mono,Menlo,Consolas,monospace;font-size:12.5px;line-height:1.7;padding:16px;border-radius:10px;margin:12px 0;overflow-x:auto}.math-block .label{color:#94a3b8}.math-block .answer{color:#34d399;font-weight:600}.pricing-snapshot{background:linear-gradient(135deg,#f0f9ff,#eff6ff);border:1px solid #BFDBFE;border-radius:12px;padding:18px}.pricing-snapshot h3{margin-top:0}.pricing-snapshot .stat-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:12px;margin-top:12px}.pricing-snapshot .stat{background:#fff;border:1px solid #BFDBFE;border-radius:8px;padding:12px}.pricing-snapshot .stat-label{font-size:10px;font-weight:700;text-transform:uppercase;letter-spacing:.08em;color:var(--ocr-mute);margin-bottom:3px}.pricing-snapshot .stat-value{font-size:22px;font-weight:800;color:var(--ocr-text);font-variant-numeric:tabular-nums;line-height:1.1}.pricing-snapshot .stat-note{font-size:11px;color:var(--ocr-mute);margin-top:3px}.byline-block{display:flex;gap:14px;align-items:center;background:var(--ocr-soft);border:1px solid var(--ocr-border);border-radius:10px;padding:14px;margin-top:18px}.byline-block .avatar{width:48px;height:48px;border-radius:50%;background:#cbd5e1;flex-shrink:0;display:flex;align-items:center;justify-content:center;color:#475569;font-size:11px;font-weight:600}.byline-block .meta{font-size:13px;color:var(--ocr-text);line-height:1.5}.byline-block .meta strong{display:block;font-size:14px;color:var(--ocr-text)}.byline-block .meta a{color:var(--ocr-blue)}.visually-hidden{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}.source-list{font-size:14px}.source-list li{margin-bottom:8px}.source-list .src-meta{color:var(--ocr-mute);font-size:12px}.drug-final-cta{background:linear-gradient(135deg,#1E3A5F 0%,var(--ocr-blue) 100%);color:#fff;padding:40px 24px;text-align:center;margin-top:56px}.drug-final-cta h2{color:#fff;margin-bottom:10px;font-size:22px}.drug-final-cta p{color:#ffffffd9;font-size:15px;margin-bottom:20px}.drug-final-cta .btn-white{background:#fff;color:var(--ocr-blue);padding:12px 24px;border-radius:8px;font-weight:700;text-decoration:none;font-size:15px;display:inline-block}@media(max-width:880px){.drug-hero{padding:22px 0 18px}.drug-hero h1{font-size:24px}.freshness-ribbon-inner{font-size:11px;padding:8px 14px;gap:4px 12px}.factcard-wrap{padding:0 16px}.factcard{padding:16px}.factcard h2{margin-bottom:10px}.tier1{grid-template-columns:repeat(2,1fr);gap:8px}.tier1 .big{font-size:18px}.tier1 .big.text{font-size:16px}.tier2 .row{grid-template-columns:110px 1fr}.tier2 .row .k,.tier2 .row .v{padding:8px 10px}.variant-callout{padding:0 16px}.toc-mobile{display:block}.drug-body{grid-template-columns:1fr;gap:0;padding:24px 16px 48px}.drug-toc{display:none}.drug-body section+section{margin-top:28px}.drug-body h2{font-size:19px}.pricing-snapshot .stat-grid{grid-template-columns:1fr}.phase-marker{margin:36px 0 16px;flex-wrap:wrap}.phase-marker .desc{margin-left:0;flex-basis:100%;margin-top:4px}}@media print{body{background:#fff!important;color:#000!important}.nav,.toc-mobile,.drug-toc,.drug-final-cta,.footer,.tier3,.variant-callout{display:none!important}.drug-hero{background:#fff!important;color:#000!important;padding:0 0 8px;border-bottom:1px solid #000}.drug-hero h1{color:#000!important;font-size:18pt}.drug-hero .brand-line,.drug-hero .breadcrumb{color:#333!important}.freshness-ribbon-inner{background:#fff!important;border:1px solid #999;color:#000!important}.freshness-ribbon .check{background:#000!important}.factcard{box-shadow:none!important;border:1px solid #000;page-break-inside:avoid}.tier1 .cell,.tier2,.pricing-snapshot,.table-wrap,.drug-table,.math-block,.callout,.byline-block{page-break-inside:avoid;background:#fff!important;color:#000!important;border-color:#999!important}.math-block{color:#000!important}.math-block .label{color:#444!important}.math-block .answer{color:#000!important;font-weight:700}.drug-body{display:block;max-width:none;padding:16px}.phase-marker{page-break-after:avoid;border-bottom-color:#000!important}.drug-body section{page-break-inside:avoid;margin-top:24px!important}.source-list a[href]:after,.drug-body section a[href^=http]:after{content:" (" attr(href) ")";font-size:9pt;color:#444;word-break:break-all}a[href^="#"]:after,a[href^="/"]:after{content:""!important}}